Wegovy vs Mounjaro: How the Two Compare
Both are once-weekly weight-loss injections, but they are not identical. A pharmacist's clear-eyed look at how they differ, without the hype.
The short version
Wegovy contains semaglutide and acts on one gut-hormone pathway. Mounjaro contains tirzepatide and acts on two. Both are given as a once-weekly injection and both are prescription-only. Beyond that, the right choice is an individual one.
How they work
Wegovy mimics a hormone called GLP-1, reducing appetite and slowing digestion. Mounjaro works on GLP-1 and a second hormone called GIP, which is why it is sometimes described as dual-action. Both aim for the same outcome: less appetite, steadier eating, and gradual, sustainable weight loss alongside diet and activity.
There is no single best injection, only the one that is right for you. The decision belongs with your prescriber, based on your health and history. Our job is to make sure you understand it and feel supported using it.
Dosing and what to expect
Both start at a low dose that steps up gradually to reduce side effects, and both are stored in the fridge until use. Side effects are broadly similar, mostly digestive and usually easing with time. The step-up schedules and maintenance doses differ between the two.
Which is right for you?
That decision rests with your GP or prescriber, taking account of your health, your history and what is suitable and available for you. Whichever you are prescribed, we dispense it, support you through the programme, and are here for every question along the way.
This article is general information from our pharmacy team, not a substitute for individual medical advice. A prescription is required for any prescription-only medicine, and your GP or prescriber decides what is right for you. If you are worried, please talk to us or your GP.
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Our pharmacists at Abberley Court, Tallaght, open until 9pm Monday to Friday. This article is general information and is not a substitute for personal medical advice.
